• About Flourish Clinic
  • Services
    • CIRS Treatment
    • CIRS Counselling
    • Massage
      • Red Light Therapy
      • Lymphatic Drainage
  • Specialties
    • Chronic Fatigue Syndrome Specialist
    • CIRS / Mold Sickness
  • Flourish Treatment Programs
    • Treating Chronic Illness & CIRS
    • Shoemaker Protocol Course Login
  • FAQ
  • Schedule An Appointment
  • Contact
  • Call Us Today! (403) 907-0464
  • Contact Us
  • Free CIRS eBook
logo-flourish-header
  • About Us
  • Services & Specialties
    • Chronic Fatigue Syndrome Specialist
    • Fibromyalgia
    • CIRS
    • CIRS Counselling
    • Massage Therapy
      • Lymphatic Drainage
      • Red Light Therapy
  • Resources
    • What Is CIRS?
    • Symptoms of CIRS
    • What Causes CIRS
    • How to Treat CIRS
  • Flourish Treatment Programs
  • Book an Appointment
  • Contact Us
  • Free CIRS eBook
You are here: Home / Clear Focused Mind / Could Your Fatigue Be Caused By Mast Cell Activation Syndrome?
Could Your Fatigue Be Caused By Mast Cell Activation Syndrome?

Could Your Fatigue Be Caused By Mast Cell Activation Syndrome?

Last Updated on: September 25, 2024 by Mark Volmer

Those incredibly strange symptoms of yours… The debilitating fatigue. The other ones no doctor can make sense of. The same symptoms that make you question your sanity…

Those could all be the result of a strange condition known as mast cell activation syndrome.

Of all the strange illnesses that contribute to chronic fatigue, mast cell activation may be the most poorly understood. Which means that you’re going to need to know everything you can about this strange syndrome.

I’ll help you do just that in this post!

Much like chronic fatigue syndrome, mast cell activation syndrome is not something your family doc is going to have in-depth knowledge on. At best you’ll probably leave his or her office with a prescription for an antidepressant. At worst, you’ll be told that your symptoms are not real and that they are all in your head.

Your symptoms are not in your head. They’re very real. Today, I’m going to help you better understand mast cell activation syndrome. And how it could be the root cause of your fatigue.

Let’s jump in!

What the heck is a mast cell?

Mast cells are also known as mastocytes or labrocytes. Each of those words is referring to the same type of cell.

And your body is composed of many different types and quantities of cells. Mast cells make up a small percentage of the total number of cells in your body. However, even though they don’t take up a lot of space in your body, mast cells can have an intense effect on nearly all of your body’s systems.

The defining characteristic of mast cells is that they contain histamine. Now the word histamine may sound familiar, especially if you suffer from seasonal allergies and need to take anti-histamines. Histamine is the substance your body releases during times of inflammation.

And it’s your mast cells that are responsible for that release! You have mast cells to thank for those seasonal allergies of yours. They are the culprits behind your runny nose, tearing eyes, and itchy skin.

But allergies and inflammation aren’t the only roles of histamine and mast cells. They are also incredibly important in regulating your stomach acid production, acting as a neurotransmitter in your brain, and keeping your immune system in check. (1)

So all those weird symptoms you’ve been suffering from – they could be coming from your mast cells and the histamine they release! In fact, even your fatigue could be triggered by your mast cells.

The weird and wacky symptoms associated with mast cell activation syndrome

If you’re dealing with mast cell activation syndrome, you’ve probably been told that your symptoms don’t make sense. And that they must be in your head. You’ve possibly even been referred to psychiatrists.

By the time I see a patient with mast cell activation syndrome, she has come to believe that the symptoms must be in her head. That’s why I need to take the time to understand all of her symptoms. No matter how weird or wacky they may sound.

Below, I give you a list of the more common symptoms I see associated with mast cell activation syndrome. Please note that not all of these symptoms are recognized by the American Academy of Allergy Asthma and Immunology (AAAAI). I’ve combined both my clinical experience and the recognized symptoms in the below list. (2)

Mast cell activation symptoms

  • Fatigue
    • Often these patients will have a diagnosis of chronic fatigue syndrome.
  • Intense anxiety and/or depression
  • Severe pain that can localize to joints, muscles, tendons or bones
  • Strange neurological symptoms
    • numbness
    • tingling
    • pseudoseizures
  • Headaches
  • Ringing in the ears
  • Sensitivity to a wide variety of stimuli including:
    • light
    • touch
    • foods
    • smells
    • chemicals
  • Swollen lymph nodes
  • GI issues including:
    • diarrhea
    • constipation
    • bloating
    • gas
    • distension
  • Insomnia
  • Cognitive challenges including:
    • brain fog
    • decreased ability to focus
    • decreased memory
    • Challenges concentrating
  • Skin rashes
  • Challenges with balance or equilibrium

If you have all of the above symptoms (and possibly more!) it’s time to to start looking into mast cell activation syndrome.

It’s also worth looking into mast cell activation syndrome if you’ve been diagnosed with Lyme disease, chronic fatigue syndrome, fibromyalgia, or IBS.

Read on for the specifics of how your mast cells get activated and more importantly, how to deactivate them!

Happy mast cells vs angry mast cells 

Your mast cells help your immune system liaise with the outside world. The areas of your body that most often come into contact with the outside world include your GI tract, sinuses and respiratory tract, skin, and genital/urinary tract. This is also why the majority of the symptoms associated with mast cell activation syndrome affect those systems!

When your mast cells come into contact with an invader – think virus, bacteria, or some other unwanted guest – they sound the alarm bells. In the body, the alarm bells are actually signaling molecules. Mast cells release histamine, serotonin, or tryptase as signaling molecules that let your other cells know there’s an intruder.

When your mast cells are happy, they simply patrol your body looking for unwanted guests. When they identify an intruder, they signal the alarm. Your immune system swoops in and removes the unwanted guest. This is how your mast cells should function. But all too often something goes awry.

Angry mast cells are known as activated mast cells. They’re the overeager new bouncer that kicks absolutely everyone out of the bar; even the patrons who are behaving. When your mast cells become activated they no longer pick and choose when to respond. Instead, they respond to absolutely everything they encounter.

Happy mast cells allow you to go about your life without issue.

Angry mast cells think the food you eat, the air you breathe, and just about everything else you encounter is a threat.

If you find yourself overly reactive to foods, smells, sounds, chemicals, touch, and just about everything else, look to your mast cells. Happy mast cells allow you to comfortably interact with your environment. Angry mast cells react to just about anything!

Food allergies are not the same as mast cell activation syndrome

Nearly all of my patients with mast cell activation syndrome arrive at the clinic utterly confused about what to eat. They’ve almost always done either food sensitivity testing or an elimination diet with a previous practitioner. Yet they still cannot tell which foods their body tolerates and which foods cause a reaction.

Here’s why:

Food allergies or sensitivities are different than mast cell activation syndrome.

They’re very, very different. Even if your food sensitivity test says you can eat tomatoes, you may still find tomatoes cause an intense, unwanted reaction within your body.

Food allergies and sensitivities are consistent. The results are reproducible. If you have non-celiac gluten sensitivity then every time you eat gluten you’ll feel sick. Activated mast cells are totally inconsistent. Some days you may find your body loves and tolerates tomatoes. Other days, you’ll find tomatoes cause all sorts of crazy symptoms.

If you’re utterly confused about which foods cause a reaction in your body, look to your mast cells.

How do you diagnose mast cell activation syndrome?

Diagnosis is no cakewalk. Your mast cells release over 200 different substances! Knowing which is the right one to measure is like finding the proverbial needle in a haystack. To further complicate matters, substances like histamine degrade minutes after being released. This makes catching elevated levels in your blood even trickier.

Before any lab testing, start with your symptoms. Symptoms point in the direction of mast cell activation syndrome. Go through the list of symptoms above. If you’re dealing with nearly all of them, you should start considering mast cell activation syndrome.

Another hallmark sign of mast cell activation syndrome is utter confusion surrounding which foods you tolerate and which foods provoke a reaction in your body. If the foods you tolerate changes from one day to another, this should get you thinking about overactive mast cells.

Another sign that points in the direction of mast cell activation syndrome are your previous diagnosis. A diagnosis like chronic fatigue syndrome, fibromyalgia, or IBS could actually be the result of overactive mast cells. If your doctor diagnosed you with one of those vague conditions, further investigation in the health of your mast cells is warranted.

Getting the right diagnosis

But symptoms aren’t a concrete diagnosis. Lab tests are. Fortunately, there are a number of labs you can run to help identify if your mast cells are misbehaving. Below I give you a list of some of the current testing options for mast cell activation syndrome:

  • Total serum tryptase
  • Chromogranin A 
  • Urinary N-methylhistamine
  • Leukotriene E4

Unfortunately all of these tests are incredibly specialized. If you’re working within the conventional medical system, it’s likely that the only way you will be given these tests will be after consulting with a hematologist. It’s highly unlikely that your family physician (unless he/she is functionally trained) will be able to order these labs.

Practitioners working within the functional medicine paradigm will be able to run the above labs through either Quest Diagnostics or LabCorp.

Now that you know exactly what mast cell activation syndrome is and how to properly diagnose it, let’s jump into treatment. To be clear, mast cell activation syndrome tends to be a symptom of another illness. Said another way, your mast cells become destabilized by an infectious agent.

Proper treatment needs to identify and remove the infectious agent. In the next section, I’ll show four hidden causes of angry mast cells!

Four hidden causes of mast cell activation syndrome

The most important part of treatment is to identify the underlying illness that is causing your mast cells to activate. Often, this is due to an undiagnosed infection. Some of the more common infections that trigger mast cell activation disorder include:

  1. Hidden gut infections
  2. Toxic mold
  3. Heavy metals
  4. Lyme disease

Hidden gut infections

If you’re dealing with an overgrowth of bacteria, viruses, or fungi in your gut, your mast cells are going to be overly active. (3) That means you and your practitioner need to be on the lookout for infections like SIBO, candida, and other intestinal parasites. I recommend performing a SIBO breath test and comprehensive analysis of a stool sample.

Toxic Mold

Molds and their associated mycotoxins are almost always the root cause of mast cell activation syndrome and/or chronic fatigue syndrome.

Don’t think for a second that because you don’t see any mold in your house that you’re safe. About 50% of all homes and commercial buildings are estimated to have water damage. Mold tends to grow in areas that you can’t see. Think HVAC systems, crawl spaces, and attics.

I’ve done a deep dive into Chronic Inflammatory Response Syndrome (CIRS) and toxic mold in this post. If you’re not familiar with CIRS, be sure to check it out!

Mold triggers an inflammatory response within your body. In more than 20% of the population this inflammatory response cannot be turned off. Part of the response involves histamine and your mast cells. This is why mold may be the root cause of your rash.

Research suggests that mold could very well be at the root cause of your mast cell activation. (4) So, if your symptoms fit with too much histamine, be sure you find a mold-literate practitioner!

Heavy metals 

Toxicity caused by a build-up of heavy metals can destabilize mast cells. (5) If you have old-style amalgam (mercury) fillings they could be at the root of your chronic fatigue or mast cell activation syndrome.

Lyme disease

Lyme is one of the more complicated infections your body has to contend with. The Borrelia bacteria found in Lyme disease can trigger your mast cells. In order to calm your mast cells, Lyme disease and all the co-infections associated with it need to be remediated.

Of the three toxins I mentioned (mold, heavy metals and Lyme disease), mold is the one I see most often in the clinic. If you suspect mold is triggering your symptoms, take my mold symptoms questionnaire to see if mold could be at the root of your problems.

Can your diet improve mast cells?

I need to emphasize that diet alone will not fix mast cell activation syndrome. With that said, alterations to your nutrition can help improve your symptoms.

The most common recommendation is a low histamine diet. (6) I’ve found that the low-histamine diet is one of – if not the most – restrictive nutrition plans you can follow. It’s very difficult to sustain over the long term. But if it helps to improve your symptoms, adhering to a low-histamine diet may be helpful.

My personal recommendation to most patients is to follow a low-carb, high fat, or ketogenic diet. This diet is relatively low in histamines yet is far easier to follow than a low-histamine diet.

More treatment options for mast cell activation syndrome

You cannot supplement yourself out of mast cell activation syndrome. There’s no doubt that supplements work. But they will not help you find and treat the root cause. To successfully treat mast cell activation syndrome, you must look to the four hidden root causes:

  1. Hidden gut infections
  2. Toxic mold
  3. Heavy metals
  4. Lyme disease

Treating any of the above root causes will take time. Often, lots of time. In the interim, it’s important to help improve your symptoms. Below, I’ll give you my recommendations on the supplements best suited to stabilize your mast cells.

Quercetin

A common prescription medication to help stabilize mast cells is called cromolyn. But cromolyn is actually not as effective as quercetin when it comes to stabilizing your mast cells. (7) Quercitin is in the same family of vitamins as vitamin C. You’ll find high amounts of quercetin in raw fruits, veggies, and greens.

I default to Dr. Neil Nathan’s recommendations on dosing quercitin for patients with mast cell activation syndrome. Start with 500mg once a day. Take this dose 30 minutes before a meal.

Taking quercetin before you eat is extremely important. Remember, the goal is to help stabilize your mast cells. Food often destabilizes them. Therefore, you need to consume quercetin before eating.

Dr. Neil Nathan recommends increasing your quercetin dose – as long as you tolerate it –  up to 2000mg before each meal. Just remember to start increasing your dose slowly. Make sure you tolerate the supplement well before increasing your dose.

Diamine Oxidase

Diamine oxidase or, DAO, is an enzyme your body creates to help break down histamine. Under normal conditions, you have relatively small amounts of DAO in your blood.

When you’re dealing with mast cell activation syndrome, you’re going to want a much higher level of DAO in your blood. This will help your body digest the excess histamines.

I use the DAO products from two different companies:

  • Seeking Health Histamine Block
  • Xymogen’s HistDAO

Taking this supplement with quercitin before meals can help reduce the symptoms associated with overactive mast cells.

Quails egg

Remember how I said one of the common substances released by mast cells is something called tryptase?

Quail’s egg contains ovomucoids which block the binding of tryptase. This should help stabilize your mast cells. I recommend using the AllQlear supplement.

Treatment tips and tricks for mast cell activation syndrome

Sometimes, you need to address the symptoms of mast cell activation syndrome before treating the root cause.

If you’ve attempted treatment for toxic mold, Lyme disease, heavy metal toxicity, or hidden gut infections but found that your symptoms always flare up to unmanageable levels, you need to calm your mast cells before treating the underlying or root cause.

Start by altering your diet to a low-carb, high fat/keto diet. If that alone doesn’t improve your symptoms, add the supplements I mentioned to help stabilize your mast cells. Once your symptoms are more tolerable, then it’s time to – slowly – start treating the root cause of your mast cell activation syndrome.

Check out all my other writings on how to achieve a clear, focused mind here. 

Ok, now it’s time for me to hear from you!

What sort of strange symptoms did your mast cells cause in your body?

How did you stabilize your mast cells?

Leave your answers in the comments section below!

Do you need help improving your fatigue?

Clear Focused Mind, Symptoms of CIRS

Recent Posts

A Shoemaker Protocol practitioner ready to offer treatment for CIRS at Flourish Clinic

What is the Shoemaker Protocol?

chronic inflammatory response syndrome

Chronic Inflammatory Response Syndrome: Treatment & Recovery Tips

can mold cause fatigue

Can Mold Cause Fatigue?

Comments

  1. Lauren says

    January 10, 2020 at 1:18 PM

    Hello. I woke up one day covered in hives. Head to toe. I hadn’t eaten anything out of tbe ordinary, and I’ve never had bad allergies before other than seasonal. As days passed I had terrible diarrhea and my hives didnt improve, even on Benadryl. I went to the E.R. but they just told me to take Benadryl. More time passed and I would occasionally get mild lip or eyelid swelling, on top of hives. My doctor prescribed me Zyrtec and it helped, a lot. I still get occasional lip swelling (mild) and diarrhea but it seems my food sensitivities alter from day to day. I switched to a low histamine diet, low carb, and starting taking Quercitin and Vit. C, and I can be good for a few weeks, then bam, I have a reaction to something. Doctor didn’t feel it necessary to test for gut infection since the diarrhea goes away, so I’m wondering if its a mold issue.

  2. Mark Volmer says

    January 15, 2020 at 8:01 AM

    Hi, Lauren,

    Good call on trying out the low histamine diet. I’ve also found a lot of my mold patients respond well to a ketogenic diet. More info on that here.

    I’ve seen mold be the root cause of out of control mast cells many times. I’d recommend finding and working with a mold-literate practitioner!

    Keep me posted!

    M

  3. Heather says

    March 23, 2020 at 5:23 PM

    I’ve known for a couple years that I seem to have mast cell activation disorder, and it came from mold in the house. I knew it caused itching and lots of new allergies to things I wasn’t allergic to before. I just never knew that it could contribute to fatigue, and I am sooo fatigued. One baffling symptom is that I get profoundly sleepy after meals, and it isn’t just a blood sugar reaction. This can happen after a protein meal or anything. Is this a mast cell response? I have been taking quercetin, but not per your directions. I will try the timing before meals. Thank you.

  4. Mark Volmer says

    March 24, 2020 at 8:27 AM

    Hi, Heather,

    It could be a mast cell response. But it sounds more like a response to mold. If the quercetin doesn’t help, check out these two articles on mold/CIRS and fatigue:

    – https://fatiguetoflourish.com/chronic-fatigue-symptom-of-toxic-mold/
    – https://fatiguetoflourish.com/whats-the-difference-between-mold-allergy-and-chronic-inflammatory-response-syndrome/

    M

  5. Robert says

    May 15, 2020 at 12:03 AM

    Hi, thanks for your article . I believe I have most of the symptoms listed … I’ve been dealing with deliberating symptoms for over 10 years and it’s funny that you brought up Lyme … I was tested for Lyme after receiving a bite from a bug… I tested negative for Lyme and a few months later , I started developing all of these symptoms with chest tightness…sensitivity to temp and foods like TOMATOES… and oranges ….and then maybe 3 years ago numbness and MS. I think all of this is related but who knows… I would love to stabilize my active mast cells though if I have the syndrome.

  6. Mark Volmer says

    May 21, 2020 at 10:50 AM

    Hi, Robert,

    Testing for Lyme disease is a mess. Depending on which test you had done, the false-negative rate can be upwards of 90%.

    What you may be dealing with is a condition known as Chronic Inflammatory Response Syndrome (CIRS). More info on all things CIRS here – https://fatiguetoflourish.com/whats-the-difference-between-mold-allergy-and-chronic-inflammatory-response-syndrome/

    M

  7. Katja says

    July 22, 2020 at 6:26 PM

    Hi Mark, It looks like I developed a Mast Cell Disorder following Covid. I’m trying to get to see an immunologist. I’m tried clicking on the above DAO products but neither of them is available. Any other suggestins? Also, you talk about treating the underlying disorder. In your opinion, can I expect to get relief and I continue to heal from the virus?

    Thanks, Katja

  8. Mark Volmer says

    July 23, 2020 at 1:53 PM

    Hi, Katja!

    Bifido probiotics can be a great help in stabilizing mast cells. As can quercetin.

    I wish I had more insight regarding COVID but since the information is so new, we likely won’t have that data for some time. What I suspect is that those with specific HLA mutations will be at increased risk for complications following infection.

    More info on all things HLA here – https://fatiguetoflourish.com/whats-the-difference-between-mold-allergy-and-chronic-inflammatory-response-syndrome/

    M

  9. Jo says

    April 5, 2021 at 1:20 PM

    Hello Mark,
    My naturopath figured out that my mercury fillings caused my MCAS. So I’m trying to detox at the same time as calming my mast cells. I have horrible time concentrating, have hard time with cognition, headaches, body aches, major brain fog, not too many digestive issues.
    I take dao, but no quercitin , i guess I should try. I’m taking sooo many supplements I don’t know if I should add more…

  10. Mark Volmer says

    April 9, 2021 at 10:12 AM

    Hey, Jo,

    I agree, more is not often the answer. I suggest slowly decreasing your current supplements (1 at a time) and see if there are any changes to your symptoms. If not, you can remove said supplement.

    M

Leave a Reply

Your email address will not be published. Required fields are marked *

We have Canada’s only certified Shoemaker Protocol practitioners!

Book a complimentary call with one of our certified Shoemaker Protocol practitioners now!

Book here

Our Most Popular Articles

 

  • The CIRS Treatment Protocol Explained?
  • What are the symptoms of CIRS?
  • What is CIRS?
  • Is CIRS a real disease? 
  • The Link Between Mold & Fibromyalgia
  • How do you get rid of CIRS?
  • Is Your Headache Caused by Mold Sickness?
  • Is CIRS contagious?
  • CIRS for friends & family

Recent Posts

  • What is the Shoemaker Protocol?
  • Chronic Inflammatory Response Syndrome: Treatment & Recovery Tips
  • Can Mold Cause Fatigue?

Our Practitioners

Eve Paraschuk, MSW, RSW
Jane Prescot, FMCHC
Mark Volmer, R.Ac., FMP
Sheena Huculak, RHN
Steph Perryman, RMT

CIRS Treatment

What is CIRS?
How does Flourish treat CIRS?
The Shoemaker Protocol explained

  • Email
  • Facebook
  • Instagram
  • Medium

Specialties

Chronic Fatigue Syndrome
CIRS Treatment

 

Privacy Policy

logo-flourish

Contact Us

Unit 201* 1 Bow Ridge Road, Cochrane, AB, Canada T4C 2J1

403-907-0464

hello@flourishclinic.com

Connect With Us

  • Email
  • Facebook
  • Instagram
  • Medium

Services & Specialties

CIRS Treatment

Fibromyalgia

Chronic Fatigue

CIRS Counselling

Massage Therapy

Our Practitioners

Mark Volmer, R.Ac., FMP

Jane Prescot, FMCHC

Eve Paraschuk, MSW, RSW

Sheena Huculak, RHN

Steph Perryman, RMT

Resources

Flourish CIRS Treatment Program

What is CIRS?

Symptoms of CIRS

What Causes CIRS?

How to Treat CIRS