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You are here: Home / Symptoms of CIRS / What does Lyme Disease Fatigue Feel Like?
What does Lyme Disease Fatigue Feel Like?

What does Lyme Disease Fatigue Feel Like?

Last Updated on: March 10, 2025 by Mark Volmer

What Does Lyme Disease Fatigue Feel Like?

When you have fatigue from Lyme Disease, you don’t get to wake up every day feeling refreshed and ready to take on the day.

Instead, waking up brings the feeling that your body has been anchored to the bed. Your exhaustion is unrelenting; not the kind you shake off with a cup of coffee. You manage to get up, but every step feels like walking through wet cement. You tell yourself it’s just stress or lack of sleep, but deep down, you know something’s not right.

This is what many people with Lyme disease describe. Yet, for some, it’s not Lyme disease at all—it’s something deeper, more complex, and often misdiagnosed: Chronic Inflammatory Response Syndrome (CIRS). Let’s dive into what Lyme disease fatigue feels like, why it happens, and if it is Lyme that is causing your fatigue or if it’s time to explore CIRS.

Lyme Disease Fatigue: The Basics

Lyme disease is caused by Borrelia burgdorferi, a bacteria transmitted through tick bites. It’s often accompanied by symptoms like joint pain, brain fog, and the hallmark bullseye rash. However, fatigue remains one of Lyme disease’s most debilitating effects.

Lyme disease Stats You Should Know:

  • In the USA, the CDC estimates about 476,000 cases of Lyme disease annually.
  • In Canada, Lyme disease cases have risen dramatically, with more than 3,000 reported cases in 2022, though the real number may be higher due to underreporting.
  • In Europe, Lyme disease affects up to 360,000 people annually, making it a growing public health concern.

Despite these figures, many Lyme patients find themselves in diagnostic limbo. Blood tests can be unreliable, and symptoms often overlap with conditions like fibromyalgia and chronic fatigue syndrome (CFS).

How Lyme Disease Fatigue Feels Different

Fatigue from Lyme disease is not ordinary tiredness. Here’s what patients often report:

  1. Unpredictable Energy Crashes: One moment you’re fine, the next you feel like your battery has hit zero.
  2. Debilitating Exhaustion: Basic tasks—showering, cooking, or even holding a conversation—become Herculean efforts.
  3. Cognitive Drain: Fatigue extends to the brain, leaving you struggling to think, remember details, or focus.
  4. Sleep Doesn’t Help: No matter how much rest you get, it feels like you’re never recharged.

The CIRS Connection

Here’s the twist: many people diagnosed with Lyme disease may have CIRS. This chronic inflammatory condition occurs when your body’s immune system stays in overdrive due to biotoxin exposure, often from mold, bacteria, or Lyme itself.

Why CIRS Mimics Lyme Disease:

  • Both conditions cause systemic inflammation, leading to fatigue, brain fog, and pain.
  • In CIRS, exposure to biotoxins triggers a cascade of immune responses that your body can’t shut off, resulting in symptoms that overlap with Lyme disease.
  • If Lyme fatigue persists despite treatment, undiagnosed CIRS could be the real culprit.
  • You could have both Lyme disease and CIRS.

What Most Websites Don’t Tell You

Most Lyme resources focus on antibiotics or alternative treatments, but few mention:

  • Testing for CIRS: Tools like the Visual Contrast Sensitivity (VCS) test or specific lab markers (e.g., MSH, TGF-beta1) can help identify CIRS.
  • Endotoxins and Fatigue: Chronic exposure to endotoxins from bacteria like Borrelia can affect your brain’s grey matter, exacerbating fatigue.
  • Mold Exposure: Up to 50% of CIRS patients have mold-related illness, which is often missed in traditional Lyme treatment.

Finding Help for Lyme Disease Fatigue and CIRS

At Flourish Clinic, we specialize in addressing the root causes of chronic fatigue. If you’ve been diagnosed with Lyme disease but still feel exhausted, we can help you determine whether CIRS is playing a role.

Your first step is running a GENIE test. This blood test not only tells us if you have CIRS, but also if Lyme is in fact contributing to your health issues. It is the only blood test in the world that looks at your mitochondrial RNA, which is the epicentre of your fatigue.

After we receive the results of your GENIE, our personalized protocols focus on biotoxin removal, immune system balancing, and restoring energy levels so you can get your life back.

Living with unrelenting fatigue is isolating and frustrating, especially when answers feel out of reach. Whether it’s Lyme disease, CIRS, or something else, you deserve a thorough investigation and compassionate care. What if the key to overcoming your fatigue lies in understanding its true source?

What’s your next step in finding relief from Lyme disease fatigue?

 

Mark Volmer has attained the highest level of Shoemaker Protocol certification, and is one of only two of Canada’s Shoemaker Protocol practitioners. The Shoemaker Protocol is the only scientifically proven method of treating CIRS.

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